Dr Siu has been actively engaged in research related to microbial genomics. He has published over 50 peer-reviewed research papers in high-impact academic journals, including Lancet Respiratory Medicine and Clinical Chemistry. During the pandemic, his rapid sequencing technique has been crucial in identifying and stopping local transmission chains of the virus, earning him the Outstanding Project Team on COVID-19 Research Award from the Food and Health Bureau. He was also honoured by the University with a faculty research and teaching award for two consecutive years, and has been appointed as Limin Endowed Young Scholar in Medical Laboratory Science. Besides, he has been appointed by the Government as a Member of the Medical Laboratory Technologist Board, chairing its Education Committee and Examination Committee.
He is a recipient of the Outstanding PolyU Young Alumni Award in Scholarly Achievement.